Anti-obesity drug that melt fat without curbing appetite
Galveston scientists at University of Texas have developed the new (weight loss) anti-obesity drug. According to the study published in journal Biochemical Pharmacology, the drug has potential to fight obesity by burning fat cells without suppressing appetite.
However, the preliminary research is conducted on mice. Still the mechanism of fat burning pill is arousing the public curiosity. In the study mice were provided with enough food until they become obese. Then they were fed with the drug. The drug increases the cellular metabolism of obesity-linked white fat cells. After 10 days of treatment the associated fat cells shrink 30% in size as compare to those mice that were on placebo. During that time, the both group mice have fed with the same amount of food. The drug-taking mice lost more than 7% of their total body weight. Moreover, the blood cholesterol level also returned to normal in the drug-taking mice.
The anti-obesity drugs and weight loss could also prevent other conditions to develop such as type 2 diabetes and heart diseases. A recent research by Harvard conclude the fact about America children who are going to be obese by the time they are 35. However, 40% of adults in US are currently obese.
The fat cells in the body overexpress a protein that is known as metabolic brake. It slows down the fat burning mechanism and thus starts fat accumulation. The accumulating fat tissues thus secrete hormones and pro-inflammatory signals in a greater amount. This becomes the major cause of several chronic diseases such as, type 2 diabetes and cardiovascular disease.
The study is a hope to overweight people who are unable to change their diet to fight obesity. The drug is also suitable as it did not suppress appetite compare to the common obesity fighting approaches such as bariatric surgery. The fat metabolism will lead to tackle the obesity to its root level rather than mere behavioral changes. However, it may seem interesting that the researchers notice that in mice every experiment condition has been cure. So, further human clinical trials are may need by FDA to approve the drug.Techmasair